Research Areas
The Avgousti Lab is focused on the mechanisms by which viruses hijack chromatin. Due to the major advancement in sequencing technologies and the expansion of the field of epigenetics, exploiting viruses to investigate chromatin biology has enormous potential. Our goal is to advance basic understanding of viral manipulation of chromatin and uncover new aspects of chromatin biology and virus infection.
Adenovirus and protein VII
We are interested in how adenovirus manipulates host chromatin through protein VII and more broadly how DNA viruses use histones or histone-like proteins for dual function: to compact their genomes and control host genomes.
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Adenovirus and protein VII
Human cytomegalovirus (HCMV)
We are interested in the chromatin perturbations that underlie HCMV-induced dramatic nuclear and cellular changes and their impact on cellular function.
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Human cytomegalovirus (HCMV)
Herpes simplex virus (HSV-1)
We are focused on the chromatin perturbations induced by HSV-1 lytic infection and how the virus exploits these changes for viral gain.
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Herpes simplex virus (HSV-1)
Your work here
Are you interested in how viruses manipulate chromatin? Are you excited to discover unknown facets of molecular biology? If so, we’d love to hear from you!
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